• you are allergic to any ingredient in Lotrisone
• you are taking pimozide or an ergot alkaloid (eg, ergotamine).

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Lotrisone. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have diaper rash, eczema, measles, tuberculosis (TB) or a positive TB skin test, chickenpox, shingles, or thinning of the skin
• if you have recently received a vaccination.

Some medicines may interact with Lotrisone. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Clarithromycin because the risk of certain side effects may be increased
• Barbiturates (eg, phenobarbital), carbamazepine, hydantoins (eg, phenytoin), or rifampin because they may decrease Lotrisone's effectiveness
• Ergot alkaloids (eg, ergotamine), imatinib, live vaccines, macrolide immunosuppressants (eg, tacrolimus), pimozide, or ritodrine because their actions and the risk of their side effects may be increased by Lotrisone
• Hydantoins (eg, phenytoin) or interleukin-2 because their effectiveness may be decreased by Lotrisone.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Lotrisone may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

• Lotrisone is for external use only. Avoid getting Lotrisone in the eyes, vagina, mouth, or nose. If Lotrisone gets in the eyes, immediately wash out with cool tap water.
• Lotrisone has a corticosteroid in it. Before you start any new medicine, check the label to see if it has a corticosteroid in it too. If it does or if you are not sure, check with your doctor or pharmacist.
• Be sure to use Lotrisone for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The fungus could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
• Do NOT use more than the recommended dose or use for longer than prescribed without checking with your doctor.
• Do not apply Lotrisone over large areas of the body without first checking with your doctor.
• Do not use Lotrisone for other skin conditions at a later time.
• Talk with your doctor before you use any other medicines or cleansers on your skin.
• Do not use Lotrisone for diaper rash.
• Serious side effects may occur if too much of Lotrisone is absorbed through the skin. This may be more likely to occur if you use Lotrisone over a large area of the body. It may also be more likely if you wrap or bandage the area after you apply Lotrisone. The risk is greater in children. Do not use more than the prescribed dose. Contact your doctor right away if you develop unusual weight gain (especially in the face), muscle weakness, increased thirst or urination, confusion, unusual drowsiness, severe or persistent headache, or vision changes. Discuss any questions or concerns with your doctor.
• Use Lotrisone with caution in the elderly; they may be more sensitive to its effects, especially thinning skin.
• Corticosteroids may affect growth rate in children and teenagers in some cases. They may need regular growth checks while using a corticosteroid.
• Lotrisone should not be used in children younger 17 years; safety and effectiveness in these children have not been confirmed.
• Pregnancy and breast feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Lotrisone while you are pregnant. It is not known if Lotrisone is found in breast milk. If you are or will be breast-feeding while you use Lotrisone, check with your doctor. Discuss any possible risks to your baby.

Check with your doctor if any of these most common side effects persist or become bothersome:

Dry skin; mild burning or stinging at the application site.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); acne-like rash; excessive hair growth; inflamed hair follicles; inflammation around the mouth; irritation, itching, peeling, redness, blistering, swelling, oozing, or severe burning at the application site; spider veins; thinning, softening, or discoloration of the skin; unusual bruising.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.