You should not use pyridostigmine if you are allergic to it, or if you have a bladder or bowel obstruction.
To make sure you can safely take pyridostigmine, tell your doctor if you have any of these other conditions:
asthma;
kidney disease;
an ulcer or other serious stomach disorder;
high blood pressure, heart disease;
overactive thyroid; or
a history of seizures.
It is not known whether pyridostigmine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether pyridostigmine passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
Drugs interaction
Tell your doctor about all other medicines you use, especially:
atropine (Atreza, Sal-Tropine);
belladonna (Donnatal, and others);
benztropine (Cogentin);
clidinium (Quarzan);
clozapine (Clozaril, FazaClo);
dimenhydrinate (Dramamine);
methscopolamine (Pamine), scopolamine (Transderm Scop);
glycopyrrolate (Robinul);
mepenzolate (Cantil);
bladder or urinary medications such as darifenacin (Enablex), flavoxate (Urispas), oxybutynin (Ditropan, Oxytrol), tolterodine (Detrol), or solifenacin (Vesicare);
bronchodilators such as ipratropium (Atrovent) or tiotropium (Spiriva);
cold medicine, allergy medicine, or sleeping pills that contain an antihistamine such as diphenhydramine (Tylenol PM) or doxylamine (Unisom);
heart rhythm medication such as quinidine (Quin-G), procainamide (Procan, Pronestyl), disopyramide (Norpace), flecaininde (Tambocor), mexiletine (Mexitil), propafenone, (Rythmol), and others;
irritable bowel medications such as dicyclomine (Bentyl), hyoscyamine (Hyomax), or propantheline (Pro Banthine);
medicine to treat Alzheimer's dementia, such as donepezil (Aricept), rivastigmine (Exelon), or tacrine (Cognex); or
a steroid such as betamethasone (Celestone) or dexamethasone (Cortastat, Dexasone, Solurex, DexPak).
This list is not complete and other drugs may interact with pyridostigmine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.